WEIGHTLOSS

• Suppresses appetite and slows digestion (GLP-1)
• Enhances insulin response and fat metabolism (GIP)
• Boosts energy expenditure and fat burning (glucagon)

• Up to 24-28.7% average body weight loss in trials (e.g., 71+ lbs in some participants over 48-68 weeks at higher doses)
• Superior reduction in visceral/liver fat while helping preserve lean muscle
• Improved blood sugar control, insulin sensitivity, and metabolic health
• Potential added benefits for conditions like fatty liver, knee osteoarthritis pain, cardiovascular risk, and overall energy/vitality
• Once-weekly subcutaneous injection (in-office or at-home with guidance)

Administered under strict physician supervision with regular monitoring, just like our Semaglutide and Tirzepatide programs. Mild, dose-related side effects (primarily GI, such as nausea) are common initially but often improve with titration and support.

Retatrutide represents the future of medical weight loss—offering potentially greater results for those seeking aggressive, sustainable transformation. It’s an ideal complement to our holistic approach, including InBody analysis, personalized nutrition/exercise plans, peptide support (e.g., for recovery/energy), and regenerative therapies like ACORN Secretome.

No significant recovery time or downtime is required with Retatrutide. It’s a once-weekly subcutaneous injection (like semaglutide or tirzepatide), administered at home or in-office with minimal disruption to daily life. Mild side effects like nausea or mild gastrointestinal side effects may occur initially but typically subside.

Results (primarily weight loss and metabolic improvements) are maintained as long as you continue treatment, but most weight is regained if you stop completely—similar to other GLP-1-based therapies.

• During active treatment: Weight loss continues progressively (no plateau observed in many trials up to 48–68 weeks), with average reductions of 24–28.7% body weight at higher doses (e.g., 12 mg) over 48–68 weeks in phase 2/3 data. Improvements in blood sugar, insulin sensitivity, visceral fat, and related benefits (e.g., reduced knee pain in OA trials) also persist on therapy.
  
  
• After stopping: The appetite suppression, slowed digestion, and boosted energy expenditure fade as the drug clears (half-life ~6 days; fully out of system in ~30 days or so). Studies on similar drugs show 70–80% of lost weight regained within 12 months (most in the first 6 months) due to metabolic adaptations returning (e.g., increased hunger, slower metabolism). Preliminary insights for retatrutide suggest similar patterns—weight regain is expected without ongoing intervention.
  
  
• Long-term maintenance: Many achieve better retention with low-dose continuation, intensified lifestyle habits (diet/exercise), or cycling protocols. In trials, weight loss trajectories didn’t plateau while on treatment, so sustained use supports ongoing benefits.

Results vary by individual factors (adherence, lifestyle, starting weight), but the key is viewing it as a long-term tool for metabolic health, not a short “fix.”

Preparation focuses on medical screening, education, and lifestyle setup under physician supervision—essential since it’s a potent therapy.

• Medical evaluation/consultation (most important step): Full history and physical, bloodwork (e.g., glucose, lipids, liver/kidney function), and screening for contraindications like personal/family history of medullary thyroid carcinoma, severe GI issues (e.g., gastroparesis), pancreatitis, severe hypoglycemia risk, or certain endocrine/cardiovascular conditions. Pregnancy/breastfeeding is contraindicated.
  
  
• Discuss expectations and side effects: Review potential GI symptoms and how to manage them (e.g., start low/slow titration, eat smaller meals, stay hydrated). Your provider will tailor dosing (often starting at 1–2 mg weekly).
  
  
• Lifestyle prep: Adopt or plan for healthy eating (focus on protein, fiber, hydration to ease GI adjustment) and regular activity—trials pair it with diet/exercise for best results. No strict fasting or major changes required pre-start, but building habits helps.
  
  
• No special “prep” like fasting or avoiding food—just ensure you’re not on conflicting meds and follow provider instructions.

At a place like St. Pete Wellness MedSpa, this would tie into their personalized approach (e.g., InBody scans, peptide synergies for muscle preservation/energy during loss). Always start with a consultation to confirm eligibility and create a safe plan.